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Irinotecan Hcl Trihydrate(Campto) /


Cat.No.ABP000494 Chemical NameIrinotecan Hcl Trihydrate(Campto) / MDL: MFCD17215515 MolFormulaC33H38N4O6.ClH.3H2O MolWeight677.19

Chemical Name : Irinotecan Hcl Trihydrate(Campto) /

CAS : 136572-09-3



Irinotecan hydrochloride trihydrate is a hydrochloride trihydrate of irinotecan (Camptosar, Campto, CPT-11) which is a topoisomerase I inhibitor with IC50 of 15.8 and 5.17 μM for LoVo cells and HT-29 cells, respectively. As a Topo I inhibitor, Irinotecan (Camptosar, Campto, CPT-11) inhibits the religation step of the enzyme’s normal action, inducing single stranded DNA breaks. These single stranded breaks are then converted to double-stranded breaks within the course of DNA replication which is reported to induce apoptosis or repair mechanisms as a result. Irinotecan is activated by esterases to produce the activated metabolite and has been reported to be associated with cleavage of poly (ADP-ribose) polymerase (PARP) in colon carcinoma cells. Irinotecan’s active metabolite is additionally noted to activate p53 in the Huh7 cell line.


[1] http://en.wikipedia.org/wiki/Irinotecan

[2] Pavillard V et al. Cancer Chemother Pharmacol. 2002 Apr;49(4):329-35.