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Tubastatin A


Cat.No.ABP000154 Chemical NameTubastatin A MolFormulaC20H21N3O2 MolWeight335.3996 Purity >98%

Chemical Name : Tubastatin A

CAS : 1239262-52-2

Synonyms: N-hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)methyl)benzamide

Solubility:4 deg C

Storage:at -20℃ 2 years


Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM.1 Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC50 = 0.9 μM).1 Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.1


HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease