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Torin 2


Cat.No.ABP000908 Chemical NameTorin 2 MolFormulaC24H15F3N4O MolWeight432.3973 Purity 98%

Chemical Name : Torin 2

CAS : 1223001-51-1

Synonyms: 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[H]-1,6-naphthyridin-2(1H)-one

Storage:at -20℃ 2 years


Palomid 529 (P529) is a novel potent antitumour PI3K/Akt/mTOR inhibitor with a GI50 of <35 μM in the NCI-60 cell lines panel. Palomid 529 (P529) inhibits the TORC1 and TORC2 complexes and shows both inhibition of Akt signaling and mTOR signaling similarly in tumor and vasculature. Palomid 529 (P529) inhibits tumor growth, angiogenesis, and vascular permeability. However, Palomid 529 (P529) has the additional benefit of blocking pAktS473 signaling consistent with blocking TORC2 in all cells and thus bypassing feedback loops that lead to increased Akt signaling in some tumor cells. Palomid 529 (P529) inhibited both VEGF-driven (IC50 = 20 nM) and bFGF-driven (IC50 = 30 nM) endothelial cell proliferation and retained the ability to induce endothelial cell apoptosis. In addition, Palomid 529 (P529) significantly enhanced the antiproliferative effect of radiation in prostate cancer cells (PC-3). [1][2][3]


[1] Diaz R et al. Br J Cancer. 2009 Mar 24;100(6):932-40.

[2] Gravina GL et al. Endocr Relat Cancer. 2011 May 6.