1092788-83-4

Solubility:DMSO

Storage:at -20 2 year

Biologieal

MP470 is a multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Met, c-Kit, PDGFRalpha, Flt3, and c-Ret and with an IC50 of median 5 μM.MP470 reduced c-Met phosphorylation and enhanced radiation-induced cell kill by 0.4 logs in SF767 cells. Cells pretreated with MP470 had more ds DNA damage than cells treated with radiation alone. Mechanistically, MP470 was shown to inhibit dsDNA break repair and increase apoptosis. ^[1][2] In a study, the cytotoxicity of MP470 was evaluated on prostate cancer cell lines (LNCaP, PC-3 and DU-145). The drug was effective on LNCaP and PC-3 cells with an IC50 of ~4 μM and 8 μM, respectively. ^[3]

Reference

[1] Welsh JW et al. Radiat Oncol. 2009 Dec 22;4:69.

[2] Qi W et al. BMC Cancer. 2009 May 11;9:142.