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Cat.No.ABP000266 Chemical NameLDN193189(DM3189)/LDN-193189 MolFormulaC25H22N6 MolWeight406.4824 Purity >98%

Chemical Name : LDN193189(DM3189)/LDN-193189

CAS : 1062368-24-4

Synonyms: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

Storage:at -20℃ 2 years


A highly potent small molecule BMP inhibitor; inhibiting BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGF��1/BMP signaling) and subsequent SMAD phosphorylation; useful tool in stem cell biology. LDN-193189 shows significant in vivo clinical utility, inhibiting FOP and ectopic ossification and a potential agent in the treatment of NSCLC lung tumors.


Langenfeld and Langenfeld. Bone Morphogenetic Protein-2 Stimulates Angiogenesis in Developing Tumors. Molecular Cancer Res. 2004, 2, 141�C149. Yu et. al. BMP type I receptor inhibition reduces heterotopic ossification. Nature Medicine 2008, 14, 1363-1369. Cuny et. al. Structure�Cactivity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg Med Chem Lett. 2008, 18, 4388�C4392. Yu et. al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nature Chemical Biology 2008, 4, 33-41.