Home / Products / Inhibitors / PI3K Inhibitor / 1032754-93-0


Cat.No.ABP000111 Chemical NameGDC-0980 MolFormulaC23H30N8O3S MolWeight498.601 Purity >99%

Chemical Name : GDC-0980

CAS : 1032754-93-0

Synonyms: (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one

Storage:at -20℃ 2 years


GDC-0980 (RG7422) is a selective, dual PI3 Kinase and mTOR Kinase inhibitor with IC50 of 5, 27, 7, and 14 nM for PI3Kα, β, δ, and γ, respectively. [1] PI3 Kinase is an oncogene which is commonly mutated in cancer. The PI3K/Akt/mTOR signaling pathway modulates cell growth and survival and play a crucial role downsream of KIT signaling. GDC-0980 (RG7422) prevents mTOR with a Ki of 17 nM.


[1] Sutherlin DP et al. J Med Chem. 2011 Nov 10;54(21):7579-87.

[2] Wallin JJ et al. Mol Cancer Ther. 2011 Oct 13.