1032229-33-6
![4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide](http://stcdn.activebiopharma.com/active/ABP000839.png)
1032229-33-6
Chemical Name : 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide
CAS : 1032229-33-6
Synonyms: 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide
Solubility:DMSO
Storage:-20C 2 years
Biologieal
An orally bioavailable pan-HER tyrosine kinase inhibitor with potential antineoplastic activity. BMS-599626 inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors.
Reference
1��HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924. Haluska P et al. Mol Cancer Ther. 2008 Sep;7(9):2589-98. Epub 2008 Sep
2. 2��Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Wong TW,et al. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6186-93.
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