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Cat.No.ABP000968 Chemical NameTAK-875 MDL: MFCD18251445 MolFormulaC29H32O7S MolWeight524.625 Purity >98%

Chemical Name : TAK-875

CAS : 1000413-72-8

Synonyms: [(3S)-6-([2',6'-Dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl]methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid

Solubility:Soluble to 50 mM in DMSO and to 50 mM in ethanol

Storage:Desiccate at +4°C


Selective, non-peptide CRF1 receptor antagonist (Ki values are 2.7 and > 10000 nM for CRF1 and CRF2 receptors respectively). Blocks CRF-induced adenylate cyclase activation (Ki = 3.7 nM) and attenuates activation of the HPA axis by CRF. Displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.


Lundkist et al (1996) A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic activity. Eur.J.Pharmacol. 309 195. PMID: 8874139.

Schulz et al (1996) CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors. Proc.Natl.Acad.Sci.USA 93 10477.

Hodgson et al (2007) Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression. Pharmacol.Biochem.Behav. 86 431. PMID: 17291571.