巴瑞替尼
编号ABP001023
化学名称INCB 028050
CAS1187594-09-7
分子式C16H17N7O2S
分子量371.417
纯度 98%
化学名称 : 巴瑞替尼
CAS : 1187594-09-7
英文名称: INCB 028050
英文同义词: 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile
生物活性
Potent, irreversible human epithelial growth factor receptor 2 (ErbB2) inhibitor (IC50 = 6 nM) that displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. Exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo.-
凡德他尼中间体1
264208-69-7
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Thiazovivin
1226056-71-8
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克霉唑
23593-75-1
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2,7-二溴芘
102587-98-4
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