N-[3-[(4AS,7AS)-2-氨基-4A,5-二氢-4H-呋喃并[3,4-D][1,3]噻嗪-7A(7H)-基]-4-氟苯基]-5-氟-2-吡啶甲酰胺

主页 / 产品目录 / Others / N-[3-[(4AS,7AS)-2-氨基-4A,5-二氢-4H-呋喃并[3,4-D][1,3]噻嗪-7A(7H)-基]-4-氟苯基]-5-氟-2-吡啶甲酰胺

N-[3-[(4AS,7AS)-2-氨基-4A,5-二氢-4H-呋喃并[3,4-D][1,3]噻嗪-7A(7H)-基]-4-氟苯基]-5-氟-2-吡啶甲酰胺

编号ABP000957 化学名称LY2886721/LY-2886721/ CAS1262036-50-9 MDL: MFCD21609263 分子式C18H17FN4O2S 分子量372.422 纯度 >98%

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化学名称 : N-[3-[(4AS,7AS)-2-氨基-4A,5-二氢-4H-呋喃并[3,4-D][1,3]噻嗪-7A(7H)-基]-4-氟苯基]-5-氟-2-吡啶甲酰胺

CAS : 1262036-50-9

英文名称: LY2886721/LY-2886721/

英文同义词: LY2886721

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

AZD8330 (RRY-424704，ARRY-704) is an orally active, selective MEK inhibitor with an IC50 of 7 nM. AZD8330 (RRY-424704，ARRY-704) has potential antineoplastic activity. AZD8330 (RRY-424704，ARRY-704) specifically inhibits mitogen- activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth. Constitutive activation of this pathway has been implicated in many cancers.^[1][2]

参考文献

[1] http://www.cancer.gov/drugdictionary/?CdrID=543526