2-氨基-4-[2,4-二氯-5-[2-(1-吡咯烷基)乙氧基]苯基]-N-乙基噻吩并[2,3-D]嘧啶-6-甲酰胺

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

17 alpha-propionate is a new topical and peripherally selective androgen antagonist.
Although it displayed a strong local antiandrogenic activity in hamster’s flank organ test, it did not exhibit antiandrogenic activity in rats after subcutaneous injection, nor did it affect gonadotropins hypersecretion when injected to parabiotic rats. As topical antiandrogen, the steroid resulted about 4 times more active than progesterone and, when compared to known antiandrogen standards, it was about 3 times more potent than flutamide, about 2 times more effective than finasteride and approximately as active as cyproterone acetate. ^[1]

参考文献

[1] Celasco G et al. Arzneimittelforschung. 2004;54(12):881-6.