Tipifarnib(R115777)/zarnestra，IND 58359

Solubility:DMSO

Storage:at -20℃ 2 years

Biologieal

Staurosporine is a prototypical potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively. Staurosporine was discovered to have biological activities ranging from anti-fungal to anti-hypertensive. The interest in these activities resulted in a large investigative effort in chemistry and biology and the discovery of the potential for anti-cancer treatment. Staurosporine induces apoptosis in human neuroblastoma cell lines and chick embryonic neurons. Staurosporine is a natural product originally isolated from the bacterium Streptomyces staurosporeus.

Reference

[1] http://en.wikipedia.org/wiki/Staurosporine

[2] Matsumoto H et al. Biochem Biophys Res Commun. 1989 Jan 16;158(1):105-9.