4-[(3-溴苯基)氨基]-6,7-二甲氧基喹啉

溶解度:Soluble in DMSO at 10 mmol/L

储存条件:-20C 2 years

生物活性

Pazopanib (GW-786034) is a second-generation multitargeted tyrosine kinase inhibitor against VEGFR-1, 2 and 3, platelet-derived growth factor receptor (PDGFR)-, PDGFR-ß and c-kit.

参考文献

1. Pazopanib, a potent orally administered small-molecule multitargeted tyrosine kinase inhibitor for renal cell carcinoma. Sonpavde, G., Hutson, T.E., et al. Volume 17, Issue 2, February 2008, Pages 253-261

2. Pazopanib: a novel multitargeted tyrosine kinase Inhibitor. Guru Sonpavde, Thomas E. Hutson. 2007 Current Oncology Reports 9 (2), pp. 115-119