二氯醋酸二异丙胺

溶解度:Soluble to 100 mM in DMSO

储存条件:Desiccate at +4°C

生物活性

CB₂ antagonist/inverse agonist (K_i = 31.2 nM) that displays 165-fold selectivity over CB₁ receptors. Behaves as a weak partial/inverse agonist at CB₁ receptors.

参考文献

Hosohata et al (1997) AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain. Life Sci. 61 PL115. PMID: 9284087.

Hosohata et al (1997) AM630 antagonism of cannabinoid-stimulated [³⁵S]GTPγS binding in the mouse brain. Eur.J.Pharmacol. 321 R1. PMID: 9083796.

Landsman et al (1998) AM630 is an inverse agonist at the human cannabinoid CB₁ receptor. Life Sci. 62 PL109. PMID: 9496703.