化学名称 : 琥珀酸美托洛尔
CAS : 98418-47-4
英文名称: Metroprolol succinate/
英文同义词: METOPROLOL SUCCINATE
溶解度:Soluble to 100 mM in DMSO and to 100 mM in ethanol
储存条件:Store at +4℃ 2 years
生物活性
GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.
参考文献
Zhang et al (2007) Small-molecule synergist of the Wnt/β-catenin signaling pathway. Proc.Natl.Acad.Sci.USA 104 7444.