BAY73-4506(Regorafenib)/
化学名称 : BAY73-4506(Regorafenib)/
CAS : 755037-03-7
英文名称: BAY73-4506(Regorafenib)/
英文同义词: 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
溶解度:DMSO
储存条件:at -20℃2years
生物活性
BAY 73-4506 is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature. BAY 73-4506 binds to and inhibits VEGFR-2 and -3, and tumor cell signaling kinases (RET, KIT, PDGFR, and Raf), which may result in the inhibition of tumor angiogenesis and tumor cell proliferation. This drug shows potent, oral activity in a wide variety of preclinical xenograft models. [1]
参考文献
[1] S. Hedbom et al. Meeting:2007 ASCO Annual Meeting.Citation:Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. 25(18S):3593
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N-[3-[(4AS,7AS)-2-氨基-4A,5-二氢-4H-呋喃并[3,4-D][1,3]噻嗪-7A(7H)-基]-4-氟苯基]-5-氟-2-吡啶甲酰胺
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