8-(4-二苯并噻吩基)-2-(4-吗啉基)-4H-1-苯并吡喃-4-酮

溶解度:DMSO

储存条件:-20C 2 years

生物活性

Potent, selective and ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK), with IC50 value to be 13 nM for in vitro DNA-PK inhibition; selectivity >100 fold for DNA-PK over related kinases.

参考文献

E Willmore et al. DNA-Dependent Protein Kinase Is a Therapeutic Target and an Indicator of Poor Prognosis in B-Cell Chronic Lymphocytic Leukemia. Clin. Cancer Res. 2008, 14(12), 3984. [abstract] Y Zhao et al. Preclinical Evaluation of a Potent Novel DNA-Dependent Protein Kinase Inhibitor NU7441. Cancer Research 2006, 66, 5354-5362. [abstract] M Ljungman. Targeting the DNA damage response in cancer. Chem. Rev. 2009, 109(7), 2929-50.