RAF 265

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

RAF265(CHIR-265) is a derivative of Raf265 that is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 μM. RAF is a key component of the RAS/RAF/MEK/ERK signal-transduction pathway, which controls cell proliferation, differentiation, and apoptosis in mammalian cells. Raf265 also has anti-angiogenic activity through inhibition of vascular endothelial growth factor receptor 2 (VEGFR-2).

参考文献

[1] Mordant P, et al. Mol Cancer Ther. 2010 Feb;9(2):358-68.