非布索坦

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

Febuxostat is a non-purine selective XAO inhibitor with IC50 of 114 -210 nM. It works by non-competitively blocking the channel leading to the active site on xanthine oxidase. ^[1] Xanthine oxidase is needed to successively oxidize both hypoxanthine and xanthine to uric acid. Hence, febuxostat inhibits xanthine oxidase, therefore reducing production of uric acid.

参考文献

[1] http://en.wikipedia.org/wiki/Febuxostat

[2] Gaffo AL et al. Core Evid. 2010 Jun 15;4:25-36