SB 216763/SB-216763

溶解度:20 mg/mL in DMSO

储存条件:Storage at -20C 2 years

生物活性

Potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 9 nM for GSK-3α); competes with ATP. Has minimal activity against 24 other protein kinases (IC50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective. Also reduces pulmonary inflammation and fibrosis in a mouse model.