SB 525334/SB525334

Solubility:DMSO

Storage:at -20°

Biologieal

SB525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC50=14.3 nM). This agent inhibits TGF-β-induced ALK5 serine/ threonine kinase activity, thereby preventing phosphorylation of the Smad transcription factors and subsequent gene activation.

Reference

[1] Laping NJ. IDrugs 1999;2:907-14