Tubastatin A

溶解度:4 deg C

储存条件:at -20℃ 2 years

生物活性

Tubastatin A is a potent HDAC6 inhibitor with an IC₅₀ value of 15 nM.¹ Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC₅₀s >16 μM), excluding HDAC8 (IC₅₀ = 0.9 μM).¹ Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.¹

参考文献

HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease