Trichostatin A/TSA

Solubility:Soluble in MeOH or DMSO

Storage:-20C 2 years

Biologieal

Trichostatin A is a potent, reversible inhibitor of histone deacetylase (HDAC). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of the HDAC1 with an IC50 value of 70 nM. Trichostatin A selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA.

Reference

1 Hoshikawa, Y., Kwon, H.J., Yoshida, M., et al. Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines. Exp Cell Res 214 189-197 (1994). 2 Taunton, J., Hassig, C.A., Schreiber, S.L. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272 408-411 (1996).