AS-605240/AS605240

溶解度:DMSO

储存条件:at -20℃ 2 years

生物活性

AS-605240 is a PI3K γ inhibitor (IC50 at 8 nM), which displays 30-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα. This agent is the first examples of selective PI3K γ inhibitors, and was used to block neutrophil chemotaxis in vitro and in vivo. In passive mouse models for rheumatoid arthritis these compounds minimized progression of joint destruction.

参考文献

[1] Marone R et al. Biochim Biophys Acta. 2008 Jan;1784(1):159-85