956958-53-5

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

XL147 is a selective inhibitor of Class I PI3K isoforms. XL147 reversibly binds to class 1 PI3Ks in an ATP-competitive manner, inhibiting the production of PIP3 and activation of the PI3K signaling pathway.XL147 exhibits dose-dependent and sustained inhibition of PI3K signaling in multiple human tumor xenograft models when administered as a single agent. Administration of XL147 in combination with various targeted and chemotherapeutic agents results in enhanced anti-tumor activity in multiple xenograft models over that observed with the corresponding single agents.

参考文献

[1] G. Shapiro et al. Meeting:2009 ASCO Annual Meeting. Citation:J Clin Oncol 27:15s, 2009 (suppl; abstr 3500)