938444-93-0

D-106669

938444-93-0

编号ABP000091 化学名称D-106669 英文名称 D-106669 分子式C17H18N6O 分子量322.3644 纯度 >98%

化学名称 : D-106669

CAS : 938444-93-0

英文名称: D-106669

英文同义词: 1-ethyl-3-(3-(p-tolylamino)pyrido[2,3-b]pyrazin-6-yl)urea

溶解度:DMSO

储存条件:-20c two years

生物活性

D-106669 has been disclosed with a submicromolar inhibition of PI3Ka.Its pyridopyrazine core,substituted by an anilino residue,has been the base scaffold of a more advanced derivative AEZS-126.this molecule is described as selectitively inhibiting class I PI3K and showed some activity in A549(lung cancer)xenografts mouse model at oral dose of 30mg/kg twice daily

参考文献

Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway
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