929016-96-6

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SB939

929016-96-6

编号ABP000582 化学名称SB939 英文名称 SB939 MDL: MFCD17215206 分子式C20H30N4O2 分子量358.483 纯度 >99%

化学名称 : SB939

CAS : 929016-96-6

英文名称: SB939

英文同义词: (2E)-3-(2-Butyl-1-[2-(diethylamino)ethyl]-1h-1,3-benzodiazol-5-yl)-n-hydroxyprop-2-enamide

溶解度:DMSO to 100 mM

储存条件:at -20

生物活性

Potent and oral inhibitor of histone deacetylase (HDAC), selective for class I, II and IV HDACs. SB939 shows significant antiproliferative activity against a wide variety of tumor cell lines, with high tumor exposure and efficacy in mouse models of colorectal cancer.

参考文献

V Novotny-Diermary et al. SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer. Mol. Cancer Ther. 2010, 9(3), 642-652
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