925701-49-1

KU-60019/

925701-49-1

编号ABP000418 化学名称KU-60019/ 英文名称 KU-60019/ 分子式C30H33N3O5S 分子量547.665 纯度 >99%

化学名称 : KU-60019/

CAS : 925701-49-1

英文名称: KU-60019/

英文同义词: 2-((2R,6S)-2,6-dimethylmorpholino)-N-(4-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-7-yl)acetamide

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

KU-60019 is 10-fold more effective than KU-55933 at blocking radiation-induced phosphorylation of key ATM targets in human glioma cells. As expected, KU-60019 is a highly effective radiosensitizer of human glioma cells. A-T fibroblasts were not radiosensitized by KU-60019, strongly suggesting that the ATM kinase is specifically targeted. Furthermore, KU-60019 reduced basal S473 AKT phosphorylation, suggesting that the ATM kinase might regulate a protein phosphatase acting on AKT. In line with this finding, the effect of KU-60019 on AKT phosphorylation was countered by low levels of okadaic acid, a phosphatase inhibitor, and A-T cells were impaired in S473 AKT phosphorylation in response to radiation and insulin and unresponsive to KU-60019.

参考文献

[1] Golding SE et al. Mol Cancer Ther. 2009 Oct; 8(10):2894-902.

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