901-47-3

N-[(4-甲基苯基)磺酰基]-L-精氨酸甲酯

901-47-3

编号ABP000326 化学名称N-[(4-甲基苯基)磺酰基]-L-精氨酸甲酯 英文名称 TAME/ MDL: MFCD01320524 分子式C14H22N4O4S 分子量342.418 纯度 >99%

化学名称 : N-[(4-甲基苯基)磺酰基]-L-精氨酸甲酯

CAS : 901-47-3

英文名称: TAME/

英文同义词: TAME

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

TAME is a small molecule anaphase-promoting complex/cyclosome (APC) inhibitor with an IC50 of 12 μM. TAME binds to the APC and prevents its activation by Cdc20 and Cdh1. TAME also inhibited cyclin degradation in interphase extract activated by exogenous Cdh1, but had no effect on SCF-dependent proteolysis of β-catenin- luciferase. TAME arrested the extract in mitosis, with stable cyclin B1 and phosphorylated Cdc27. Another APC substrate, cyclinA2,was also stabilized by TAME in Xenopus extract. Besides, TAME is a potent non-airway smooth muscle constrictor with an IC50 of 43 μM in vitro. Under in vitro conditions N-alpha-tosyl L-arginine methyl ester (TAME) induced a concentration dependent contractile response on ileal strips.

参考文献

[1] Subratty AH et al. Indian J Exp Biol. 1998 Jun;36(6):618-21.

[2] Subratty AH et al. Indian J Exp Biol. 1999 Apr;37(4):406-8.

[3] Zeng X et al. Cancer Cell. 2010 Oct 19;18(4):382-95.

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