871700-17-3

GSK-1120212/GSK1120212/

871700-17-3

编号ABP000312 化学名称GSK-1120212/GSK1120212/ 英文名称 GSK-1120212/GSK1120212/ 分子式C26H23FIN5O4 分子量615.3948 纯度 98%

化学名称 : GSK-1120212/GSK1120212/

CAS : 871700-17-3

英文名称: GSK-1120212/GSK1120212/

英文同义词: N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide

溶解度:DMSO

储存条件:-20℃ 2 years

生物活性

An orally bioavailable inhibitor of mitogen-activated protein kinase kinase (MEK MAPK/ERK kinase) with potential antineoplastic activity. MEK inhibitor GSK1120212 specifically binds to and inhibits MEK 1 and 2, resulting in an inhibition of growth factor-mediated cell signaling and cellular proliferation in various cancers. MEK 1 and 2, dual specificity threonine/tyrosine kinases often upregulated in various cancer cell types, play a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth. Check for active clinical trials or closed clinical trials using this agent.

询价