869357-68-6
化学名称 : 2-(2-氟-4-碘苯氨基)-N-(2-羟基乙氧基)-1,5-二甲基-6-氧代-1,6-二氢吡啶-3-甲酰胺
CAS : 869357-68-6
英文名称: AZD8330
英文同义词: 2-[(2-Fluoro-4-iodophenyl)amino]-n-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide
溶解度:DMSO
储存条件:at -20℃ 2 years
生物活性
GSK429286A is a cell-permeable, selective inhibitor of Rho-associated kinase (ROCK). ROCKs are serine/threonine specific protein kinases which play a crucial role in organization of the actin cytoskeleton. ROCK inhibitors have been found to prevent apoptosis, as well as to enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency. Because of GSK429286A's specificity, this reagent may be useful in assessing the cellular roles of individual ROCK isoforms.
参考文献
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NSC 51773
89691-88-3
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1-(4-叔丁基苯基)-3-(4-甲氧基苯基)-1,3-丙二酮
70356-09-1
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乌地那非
268203-93-6
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BGJ398 (NVP-BGJ398)
872511-34-7
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