842133-18-0

(1S)-1,5-脱氢-1-C-[3-[[5-(4-氟苯基)-2-噻吩基]甲基]-4-甲基苯基]-D-葡萄糖醇

842133-18-0

编号ABP000358 化学名称(1S)-1,5-脱氢-1-C-[3-[[5-(4-氟苯基)-2-噻吩基]甲基]-4-甲基苯基]-D-葡萄糖醇 英文名称 Canagliflozin/ MDL: MFCD18251436 分子式C24H25FO5S 分子量444.521 纯度 >98%

化学名称 : (1S)-1,5-脱氢-1-C-[3-[[5-(4-氟苯基)-2-噻吩基]甲基]-4-甲基苯基]-D-葡萄糖醇

CAS : 842133-18-0

英文名称: Canagliflozin/

英文同义词: CANAGLIFLOZIN

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

Canagliflozin is an experimental drug being developed by Johnson & Johnson for the treatment of type 2 diabetes.[1][2] It is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. Blocking this transporter causes blood glucose to be eliminated through the urine.[3]

参考文献

  1. ^ New J&J diabetes drug effective in mid-stage study, Jun 26, 2010
  2. ^ Edward C. Chao (2011). "Canagliflozin". Drugs of the Future 36 (5): 351-357. doi:10.1358/dof.2011.36.5.1590789. 
  3. ^ Prous Science: Molecule of the Month November 2007
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