755037-03-7

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BAY73-4506(Regorafenib)/

755037-03-7

编号ABP000611 化学名称BAY73-4506(Regorafenib)/ 英文名称 BAY73-4506(Regorafenib)/ 分子式C21H15ClF4N4O3 分子量482.815 纯度 >99%

化学名称 : BAY73-4506(Regorafenib)/

CAS : 755037-03-7

英文名称: BAY73-4506(Regorafenib)/

英文同义词: 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide

溶解度:DMSO

储存条件:at -20℃2years

生物活性

BAY 73-4506 is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature. BAY 73-4506 binds to and inhibits VEGFR-2 and -3, and tumor cell signaling kinases (RET, KIT, PDGFR, and Raf), which may result in the inhibition of tumor angiogenesis and tumor cell proliferation. This drug shows potent, oral activity in a wide variety of preclinical xenograft models. [1]

参考文献

[1] S. Hedbom et al. Meeting:2007 ASCO Annual Meeting.Citation:Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. 25(18S):3593

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