化学名称 : 酮咯酸氨丁三醇
CAS : 74103-07-4
英文名称: Ketorolac Tromethamine
英文同义词: 2-Amino-2-(hydroxymethyl)propane-1,3-diol 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate;KETOROLAC TRIS SALT
溶解度:Soluble to 5 mM in ethanol and to 10 mM in DMSO
储存条件:Store at RT
生物活性
Novel positive allosteric modulator of GABAB receptor function. Potentiates the effects of GABA on [35S]GTPγS binding at recombinant and native GABAB receptors (EC50 values are 2.1 and 3.1μM respectively). Decreases cocaine self-administration, blocks the rewarding properties of nicotine and produces anxiolytic-like activity without the side effects associated with baclofen or benzodiazepines.