697761-98-1

埃替拉韦

697761-98-1

编号ABP000243 化学名称埃替拉韦 英文名称 Elvitegravir,EVG,GS-9137,JTK-303/ MDL: MFCD11846134 分子式C23H23ClFNO5 分子量447.888 纯度 99%

化学名称 : 埃替拉韦

CAS : 697761-98-1

英文名称: Elvitegravir,EVG,GS-9137,JTK-303/

英文同义词: ELVITEGRAVIR

溶解度:Unknown

储存条件:-20C 2 years

生物活性

Elvitegravir, a quinolone carboxylic acid strand-transfer specific inhibitor that displayed an IC50 of 7 nM against IN and an antiviral EC90 of 1.7 nM in the presence of NHS. In terms of pharmacokinetics, in rat and dog elvitegravir displayed a 34% and 30% bioavailability, a 2.3 h and 5.2 h half-life, and a 8.3 mL/min/kg and 17 mL/min/kg clearance, respectively.

参考文献

1. Erik Serrao, Srinivas Odde, et al. Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" HIV-1 integrase inhibitors. Retrovirology 2009, 6:25 2. Kearney B, Mathias A, Zhong L. Pharmacokinetics/pharmacodynamics of GS-9137 an HIV integrase inhibitor in treatmentnaïve and experienced patients [abstract]. International Workshop on Clinical Pharmacology of HIV Therapy. Lisbon 2006.

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