化学名称 : AS-1413(Amonafide)/Xanafide, Quinamed
CAS : 69408-81-7
英文名称: AS-1413(Amonafide)/Xanafide, Quinamed
英文同义词: AMONAFIDE
溶解度:DMSO
储存条件:at -20℃ 2 years
生物活性
AS1413 is a DNA intercalator that induces apoptotic signalling by blocking TopoII binding to DNA. Unlike classical TopoII inhibitors, a distinctive feature of AS1413 is its ability to evade PgP and related transporters responsible for multi-drug resistance. AS1413 is currently in phase III development in secondary AML.
参考文献
Phase II study of amonafide in advanced and recurrent sarcoma patients Nafidamide Clinical Brochure. The National Cancer Institute, Bethesda, MD, 1984