486460-32-6

溶解度:Soluble in water

储存条件:-20C 2 years

生物活性

Sitagliptin works to competitively inhibit the enzyme dipeptidyl peptidase 4 (DPP-4). This enzyme breaks down the incretins GLP-1 and GIP, gastrointestinal hormones that are released in response to a meal.

参考文献

1. Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys. Lee, B., Shi, L., et al. 2008, European Journal of Pharmacology 589 (1-3), pp. 306-314 2. Pharmacokinetics and pharmacodynamic effects of the oral DPP-4 inhibitor sitagliptin in middle-aged obese subjects. Herman G, Bergman A, Liu F, et al. (2006). J Clin Pharmacol 46 (8): 876�C86. doi:10.1177/0091270006289850. PMID 16855072. 3. Sitagliptin. Drucker D, Easley C, Kirkpatrick P (February 2007). Nature Reviews Drug Discovery 6: 109�C10. doi:10.1038/nrd2245.