404950-80-7

帕比司他

404950-80-7

编号ABP000143 化学名称帕比司他 英文名称 LBH-589/Panobinostat /LBH589 MDL: MFCD09833242 分子式C21H23N3O2 分子量349.432 纯度 99%

化学名称 : 帕比司他

CAS : 404950-80-7

英文名称: LBH-589/Panobinostat /LBH589

英文同义词: N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide;PANOBINOSTAT

溶解度:Soluble in DMSO

储存条件:-20C 2 years

生物活性

Panobinostat (LBH589) is also a highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumour cell proliferation in vitro. The IC50 values of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective, B61HDAC1 and B12HDAC6

参考文献

1. R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies.Arts J, Angibaud P, et al. Br J Cancer. 2007 Nov 19;97(10):1344-53. Epub 2007 Nov 13

2. Development of the pan-DAC inhibitor panobinostat (LBH589): Successes and challenges. Atadja P.Cancer Lett. 2009 Apr 1.

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