391210-00-7

PD318088/PD-318088/

391210-00-7

编号ABP000924 化学名称PD318088/PD-318088/ 英文名称 PD318088/PD-318088/ 分子式C16H13BrF3IN2O4 分子量561.089 纯度 >99%

化学名称 : PD318088/PD-318088/

CAS : 391210-00-7

英文名称: PD318088/PD-318088/

英文同义词: 5-bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzamide

溶解度:Unknown

储存条件:at -20℃

生物活性

BIX-02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM. [1] It inhibited catalytic function of purified, MEK5 enzyme. The MEK5 inhibitors blocked phosphorylation of ERK5, without affecting phosphorylation of ERK1/2 in sorbitol-stimulated HeLa cells. The compounds also inhibited transcriptional activation of MEF2C, a downstream substrate of the MEK5/ERK5 signaling cascade, in a cellular trans-reporter assay system. [2]

参考文献

[1] Tatake RJ et al. Biochem Biophys Res Commun. 2008 Dec 5;377(1):120-5

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