38748-32-2

雷藤素甲

38748-32-2

编号ABP000271 化学名称雷藤素甲 英文名称 Triptolide(PG490)/ MDL: MFCD00210565 分子式C20H24O6 分子量360.404

化学名称 : 雷藤素甲

CAS : 38748-32-2

英文名称: Triptolide(PG490)/

英文同义词: TRIPTOLIDE

生物活性

Inhibits cytokine-induced gene expression via inhibition of NF-κB transcriptional activity. Induces apoptosis in tumor cells by blocking TNF-α mediated c-IAP2 and c-IAP1 (members of the inhibitor of apoptosis family) induction. Immunosuppressive with anti-inflammatory and antitumor activity.

参考文献

Qui et al (1999) Immunosuppressant PG490 (Triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-κB transcriptional activation. J.Biol.Chem. 274 13443. Lee et al (1999) PG490 (Triptolide) cooperates with tumor necrosis factor-α to induce apoptosis in tumor cells. J.Biol.Chem. 274 13451. Liacini et al (2005) Triptolide suppresses proinflammatory cytokine-induced matrix metalloproteinase and aggrecanase-1 gene expression in chondrocytes. Biochem.Biophys.Res.Comm. 327 320.

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