371242-69-2

2-[(6-氨基-9H-嘌呤-9-基)甲基]-5-甲基-3-(2-甲基苯基)-4(3H)-喹唑啉酮

371242-69-2

编号ABP000092 化学名称2-[(6-氨基-9H-嘌呤-9-基)甲基]-5-甲基-3-(2-甲基苯基)-4(3H)-喹唑啉酮 英文名称 IC-87114 MDL: MFCD09970845 分子式C22H19N7O 分子量397.44 纯度 >98%

化学名称 : 2-[(6-氨基-9H-嘌呤-9-基)甲基]-5-甲基-3-(2-甲基苯基)-4(3H)-喹唑啉酮

CAS : 371242-69-2

英文名称: IC-87114

英文同义词: 2-[(6-Amino-9h-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H-quinazolinone

生物活性

A small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. PI3K-delta inhibitor CAL-101 inhibits the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and thus inhibiting tumor cell proliferation, motility, and survival. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells.

参考文献

1.Dose Escalation Study of CAL-101 in Select Relapsed or Refractory Hematologic Malignancies 2.Study to Investigate CAL-101 in Combination With Bendamustine and Rituximab in Patients With Relapsed or Refractory Indolent B-cell Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia

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