3613-73-8

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Dimebolin

3613-73-8

编号ABP000981 化学名称Dimebolin 英文名称 Dimebolin MDL: MFCD11521519 分子式C21H25N3 分子量319.4433 纯度 98%

化学名称 : Dimebolin

CAS : 3613-73-8

英文名称: Dimebolin

英文同义词: 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-1H-pyrido[4,3-b]indole

溶解度:Soluble to 25 mM in water and to 50 mM in DMSO

储存条件:Desiccate at +4°C

生物活性

Orally active atypical voltage-gated sodium channel blocker. Inhibits sustained sodium currents (INaL) and prevents diastolic contracture in isolated atria in vitro (IC50 values are 9.6 and 0.55 - 0.79 μM respectively). Displays anti-ischemic, bradycardic and cardioprotective activity in vivo

参考文献

Decking et al (1998) Cardioprotective actions of KC 12291. Naunyn-Schmied.Arch.Pharmacol. 358 547. Tamareille et al (2002) Anti-ischemic compound KC 12291 prevents diastolic contracture in isolated atria by blockade of voltage-gated sodium channels. J.Cardiovasc.Pharmacol. 40 346. PMID: 12198320. John et al (2004) KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties. Cardiovasc.Drug Rev. 22 17. PMID: 14978516.
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