348622-88-8

5-[(1R)-4-环己基-1-[2-(羟基氨基)-2-氧代乙基]丁基]-1,2,4-恶二唑-3-甲酰胺

348622-88-8

编号ABP000934 化学名称5-[(1R)-4-环己基-1-[2-(羟基氨基)-2-氧代乙基]丁基]-1,2,4-恶二唑-3-甲酰胺 英文名称 UK383367/UK-383367 MDL: MFCD19443866 分子式C15H18N4O4 分子量318.331 纯度 >99%

化学名称 : 5-[(1R)-4-环己基-1-[2-(羟基氨基)-2-氧代乙基]丁基]-1,2,4-恶二唑-3-甲酰胺

CAS : 348622-88-8

英文名称: UK383367/UK-383367

英文同义词: UK 383367

溶解度:DMSO

储存条件:at -20℃ 2 years

生物活性

Tipifarnib (Zarnestra, R115777, IND 58359) is a farnesyltransferase inhibitor (IC50=0.6 nM) that is used in patients 65 years of age and older with newly diagnosed acute myeloid leukemia (AML). It is also being tested in clinical trials in patients in certain stages of breast cancer. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnesylation) for signal transduction.

参考文献

[1] http://en.wikipedia.org/wiki/Tipifarnib

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