332012-40-5
332012-40-5
Chemical Name : Telatinib(BAY57-9352)/BAY57-9352
CAS : 332012-40-5
英文名称: Telatinib(BAY57-9352)/BAY57-9352
英文同义词: 4-[[[4-[(4-Chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-2-pyridinecarboxamide
Synonyms: 4-[[[4-[(4-Chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-2-pyridinecarboxamide
Solubility:DMSO
Storage:at -20℃ 2 years
Biologieal
Pelitinib is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. Pelitinib irreversibly binds covalently to epidermal growth factor receptors (EGFR) ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors. Pelitinib inhibits EGF-induced phosphorylation of EGF-R and the growth of tumors that overexpress EGF-R in animal models.
Reference
[1] http://clincancerres.aacrjournals.org/content/14/1/215.full.pdf+html
-
AZD4547/AZD-4547/
1035270-39-3
-
Gefitinib/ZD-1839,Iressa
184475-35-2
-
CI-1033(Canertinib)/PD-183805
267243-28-7
-
Erlotinib Hydrochloride/Tarceva,CP-358774
183319-69-9
浙公网安备 33010802003999号