319460-94-1

AG13958

319460-94-1

编号ABP000877 化学名称AG13958 英文名称 AG13958 分子式C26H22FN7O 分子量467.4976 纯度 98%

化学名称 : AG13958

CAS : 319460-94-1

英文名称: AG13958

英文同义词: N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

SU5402 is a multiple target inhibitor of VEGFR2 (Flk-1/KDR) and FGFR1 (IC50 at 20 and 30 nM,respectively). This agent inhibits PDGFRβ and EGFR with IC50 values of 510 nM and > 100 μM, respectively. [1]SU 5402 inhibits tyrosine phosphorylation of VEGFR2 and PDGFR in NIH 3T3 cells with IC50 values of 0.4 and 60.9 μM, respectively. This agent inhibits embryonic left-right determination and exhibits potent anticancer activity in vitro and in vivo.

参考文献

[1] Montero JA et al. Development. 2001 Jun;128(11):2075-84

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