化学名称 : RS-127445 盐酸盐
CAS : 199864-87-4
英文名称: RS 127445 hydrochloride
英文同义词: RS-127445
同义词: 2-氨基-4-(4-氟萘-1-基)-6-异丙基嘧啶; 2-氨基-4-(4-氟萘-1-基)-6-异丙基嘧啶盐酸盐;
溶解度:Soluble to 30 mM in ethanol and to 100 mM in DMSO and to 20 mM in Tocrisolve (Cat.No.1684)
储存条件:Store at +4°C
生物活性
Nanomolar affinity cannabinoid receptor agonist (Ki values are 62.3 and 3.3 nM at the human cloned CB1 and CB2 receptors respectively). Also available as part of the Cannabinoid Receptor Agonist Tocriset™. S-enantiomer WIN 55,212-3 mesylate (Cat. No. 2327) also available
参考文献
D'Ambra et al (1992) Conformationally restrained analogues of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor. J.Med.Chem. 35 124. PMID: 1732519.
Felder et al (1995) Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Mol.Pharmacol. 48 443. PMID: 7565624.
Griffin et al (1998) Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5'-O-(3-[35S]thio)-triphosphate binding assay in rat cerebellar membranes. J.Pharmacol.Exp.Ther. 285 553. PMID: 9580597.