198904-31-3

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MOC-L-叔亮氨酸

198904-31-3

编号ABP000606 化学名称MOC-L-叔亮氨酸 英文名称 Atazanavir(BMS-232632)/Reyataz MDL: MFCD08435966 分子式C38H52N6O7 分子量704.864 纯度 99%

化学名称 : MOC-L-叔亮氨酸

CAS : 198904-31-3

英文名称: Atazanavir(BMS-232632)/Reyataz

英文同义词: 3,12-Bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-, 1,14-dimethyl ester, (3s,8s,9s,12s)-2,5,6,10,13-pentaazatetradecanedioic acid;ATAZANAVIR

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

Atazanavir (Reyataz, BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once-daily (rather than requiring multiple doses per day) and has lesser effects on the patient's lipid profile (the amounts of cholesterol and other fatty substances in the blood). Like other protease inhibitors, it is used only in combination with other HIV medications. [1]

参考文献

P Pyrko. HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress. Cancer Research 2007, 67, 10920

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