192185-72-1

替吡法尼

192185-72-1

编号ABP000933 化学名称替吡法尼 英文名称 Tipifarnib(R115777)/zarnestra,IND 58359 MDL: MFCD07772347 分子式C27H22Cl2N4O 分子量489.404 纯度 >99%

化学名称 : 替吡法尼

CAS : 192185-72-1

英文名称: Tipifarnib(R115777)/zarnestra,IND 58359

英文同义词: TIPIFARNIB

溶解度:DMSO

储存条件:at -20℃ 2 years

生物活性

Staurosporine is a prototypical potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively. Staurosporine was discovered to have biological activities ranging from anti-fungal to anti-hypertensive. The interest in these activities resulted in a large investigative effort in chemistry and biology and the discovery of the potential for anti-cancer treatment. Staurosporine induces apoptosis in human neuroblastoma cell lines and chick embryonic neurons. Staurosporine is a natural product originally isolated from the bacterium Streptomyces staurosporeus.

参考文献

[1] http://en.wikipedia.org/wiki/Staurosporine

[2] Matsumoto H et al. Biochem Biophys Res Commun. 1989 Jan 16;158(1):105-9.

询价