化学名称 : Celecoxib/Celebrex, Celebra
CAS : 169590-42-5
英文名称: Celecoxib/Celebrex, Celebra
英文同义词: 4-[5-(4-Methylphenyl)-3-(Trifluoromethyl)-1H-Pyrazol-1-Yl]Benzenesulfonamide
溶解度:DMSO
储存条件:at -20℃ 2 years
生物活性
Celecoxib is a highly selective COX-2 inhibitor and primarily inhibits this isoform of cyclooxygenase (and thus causes inhibition of prostaglandin production). [1]
Celecoxib is more selective for COX-2 (IC50=0.04μM)inhibition over COX-1(IC50=15μM). [2]It binds with its polar sulfonamide side chain to a hydrophilic side pocket region close to the active COX-2 binding site. [1]
Celecoxib is a nonsteroidal antiinflammatory drug (NSAID) that is used to treat arthritis, pain, menstrual cramps, and colonic polyps. [1]
参考文献
[1] http://en.wikipedia.org/wiki/Celecoxib
[2] Neelam Seedher and Sonu Bhatia. AAPS PharmSciTech. 2003,4(3):33