162359-56-0

溶解度:Soluble in DMSO or MeOH

储存条件:-20C 2 years

生物活性

FTY720 can be phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5). IC50 of (S)- and (R)- FTY720-phosphate on lymphocyte migration toward 10 nM of S1P are 0.137 nM and 10.98 nM respectively. The IC50 values to cell lines MCF-7 (IC50=6.8��0.6µM), MDA-MB-231(IC50=6.7��0.5µM), Sk-Br-3(IC50=5.8��1.3µM), HCT-116(IC50=5.7��1.2µM), and SW620(IC50=6.7��0.6µM), are determined by WST-1 assay 48h after treatment.

参考文献

1. Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells. Nagaoka Y, Otsuki K, Fujita T, Uesato S. Biol Pharm Bull. 2008 Jun;31(6):1177-81. 2. Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate. Kiuchi M, Adachi K, Tomatsu A, Chino M, Takeda S, Tanaka Y, Maeda Y, Sato N, Mitsutomi N, Sugahara K, Chiba K. Bioorg Med Chem. 2005 Jan 17;13(2):425-32.